What is the Connection Between the Endocannabinoid System and Neuropathy?
The body’s endocannabinoid system (ECS) is what keeps us in homeostasis, through a network of cannabinoid receptors that each have the job of regulating a nearby process of the body, and through endocannabinoids, produced by the body to attach to these receptors to enable the chemical reaction that leads to regulation. The endocannabinoid system’s CB1 receptors are located in the body’s nervous system, as are much of its CB2 receptors, which explains why cannabinoids like CBD can have such powerful (and positive) effects on nervous system functions.
The endocannabinoid system’s job is to make sure that all systems of the body are operating at their highest level of efficiency. With so many cannabinoid receptors concentrated in the nervous system, it’s not surprising that cannabinoids play the role of maintaining the health of the nerves.
CBD for Neuropathy: What Does the Research Say?
CBD is the main component of the hemp plant, being the most dominant cannabinoid, not to mention chemical compound, in the plant’s makeup. It’s nontoxic to the human body, and nonintoxicating, so even high doses will not get the user high. And, ever since its discovery in 1964, it’s been studied intensively by clinical researchers and cannabis researchers for its many potential positive effects.
CBD works with CB2 and CB1 receptors, and also has a strong influence on nervous system regulation as a result. We already know many of the ways in which CBD works with the nervous system, in terms of things like mood, cognitive functions and more. Another area that has been researched quite a bit is cannabidiol’s effect on neuropathic symptoms.
Studies have consistently shown that CBD may suppress neuropathic symptoms and slow down the progression of neuropathy, by strengthening the neurons that become damaged in patients with neuropathy. One study found that the cannabinoid’s influence on 5-HT receptors that mediate serotonin production plays a big role in this process. Essentially, researchers have found that those with neuropathy have decreased 5-HT activity, and those administered CBD were able to experience higher serotonin uptake through an increase in 5-HT activity, to minimize neuropathy.
More research has shown that CBD administered topically to the affected area can offer quick and cumulative relief from symptoms like weakness, tingling and pain. The cannabinoid effectively absorbs into the local tissue to offer a more concentrated effect on the area that has experienced nerve damage.
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